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now jc has a point which has made me rethink my point of view on this topic, however a fault in your LDL receptors isn't exactly a disease now is it?
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It's a genetic disease.
I agree in general with what you are saying. I have several friends who are vastly overweight and moan about it yet do nothing about it. One in particular eats constantly, wont eat/drink anything diet/low fat etc, and he is training to be a doctor. If he was my doc and advised me to lose weight i dont think i'ld be able to keep a straight face. As far as i know he has no genetic predisposition to gain weight.
As for Prada-Willi syndrome i would guess it is to do with Leptin and the Leptin receptor seeing as they regulate how hungry you feel.